Bay Area Cardiovascular Science Symposium
Bay Area Cardiovascular Science Symposium
Watch the scientific presentations from the 2024 Bay Area Cardiovascular Science Symposium
Cardiovascular Disease16 - 30 of 1206 Results Clear All
Watch the scientific presentations from the 2024 Bay Area Cardiovascular Science Symposium
Cardiovascular DiseaseFierce Biotech—A naturally occurring mutation in T cells that leads to lymphoma can be weaponized to make engineered T-cell therapies more effective against cancer, including melanoma, findings from a new study in mice suggest. The study’s co-leads, dermatologist Jaehyuk Choi and scientist Kole Roybal, have launched a new biotech company called Moonlight Bio to take their findings to the clinic.
Research (Publication) Cancer Genomic Immunology Parker Institute for Cancer Immunotherapy Roybal Lab GenomicsAt San Francisco’s Exploratorium, visitors sync their heartbeat with living heart cells; the first-of-its-kind exhibit was created through the museum’s long-running partnership with scientists at Gladstone Institutes.
News Release Stem Cells/iPSCs Conklin Lab Yamanaka Lab Cardiovascular Disease Research (Publication)Nature—Cancer cells are the ultimate survivors, riddled with mutations that let them thrive when healthy cells would die. These same mutations can boost the ability of game-changing cell therapies to quash cancer, a study in mice shows. “Natural T-cell function isn’t good enough. We need to explore the extremes of T-cell function,” says Kole Roybal, co-author of the new paper.
Research (Publication) Cancer Genomic Immunology Parker Institute for Cancer Immunotherapy Roybal Lab GenomicsIn a new study that appears in Nature, researchers leveraged the power of a naturally occurring mutation in cancerous T cells to create a more powerful immunotherapy
News Release Research (Publication) Cancer Genomic Immunology Parker Institute for Cancer Immunotherapy Roybal LabSan Francisco Business Times—Gladstone Institutes is one of the premier training facilities in the Bay Area for training aspiring biotech researchers. Its president, Deepak Srivastava, says the the economic dip in the industry currently is presenting challenges, especially for postdoc fellow who used to be quickly scooped up into high-paying jobs in the sector, but have had more trouble finding work as funding for biotech startups dried up and layoffs abound. He says the industry needs to do more to seed this pipeline early through programs in high school and early college with people from more diverse backgrounds.
DiversityKCBS Radio—Diagnoses of autism spectrum disorder, or ASD, have been rising over the past decades, with one in 36 children identified with the condition in 2020 compared to one in 150 back in 2000, according to the US Centers for Disease Control and Prevention. Nevan Krogan, PhD, senior investigator at Gladstone Institutes and director of the Quantitative Biosciences Institute at UC San Francisco, shares new research on genetic changes that contribute to ASD.
Gladstone Experts Research (Publication) Neurological Disease Krogan LabSTAT—New research has identified proteins present in the blood of people with long COVID that could point the way to a much-needed diagnostic test and possibly to future therapeutic targets. “The dysregulation they observed is a bit complex, as some complement components go up and others go down, but overall the results suggest that complement pathways are abnormal in people with long COVID,” said Gladstone's Nadia Roan, the senior author of a Nature Immunology paper published earlier in January on immune response in long COVID.
Gladstone Experts COVID-19 Roan LabBioTechniques—Researchers at Gladstone Institutes have mapped the human immune response using next-generation CRISPR technology known as base editing. Using this tool, the team was able to identify specific nucleotides within T cells that influence immune cells’ response to stimuli, creating maps of DNA sequences and protein sites that are involved in human immune responses. The discoveries this project has facilitated could improve existing immunotherapies and reveal new drug targets for autoimmune diseases and cancer.
Research (Publication) Autoimmune Diseases Cancer Genomic Immunology Doudna Lab Marson Lab CRISPR/Gene Editing GenomicsSan Francisco Chronicle—At least 10 percent of those who survive COVID continue to face debilitating symptoms months after the acute infection resolves. New research from the laboratory of Gladstone Senior Investigator Nadia Roan shows that individuals suffering Long Covid have a dysregulated immune response to the virus and evidence of T cell exhaustion, which may be due to the virus persisting within their bodies.
Gladstone Experts COVID-19 Virology Roan LabNew research from Gladstone may help in the development of new therapies that target the problem of cellular energy failure—a hallmark of Parkinson’s, Alzheimer’s, and aging in general
News Release Research (Publication) Alzheimer’s Disease Parkinson’s Disease Neurological Disease Nakamura Lab CRISPR/Gene EditingScientists at Gladstone Institutes and UC San Francisco analyzed immune cells in people with and without long COVID, making significant discoveries that will help answer questions about what causes the condition and how to treat it
News Release Research (Publication) COVID-19 Virology Roan LabHighlights from 2023
HistoryGraduate Student Emily Bulger describes her work in the Bruneau Lab, her family roots in science, and the scientist she'd like to have a conversation with
Profile Bruneau LabThe new study from the Marson Lab represents a major stride for human genetics; findings will accelerate the development of new and better therapies for cancer and autoimmune diseases.
News Release Research (Publication) Autoimmune Diseases Cancer Genomic Immunology Marson Lab Basic Science CRISPR/Gene Editing Genomics Human Genetics